“Can thinking about death kill me?” – Thought-Action Fusion in suicidality

Imagine the following scenario: You’re waiting for your train at the station and there’s an announcement telling you to stand back for a train passing through. You see that train approaching at high speed and start wondering: “What if I walked three steps to the front and jumped?”

A very scary thought indeed and I’m sure some people reading this article will have had that thought, or a variety of it, at some point of time- I know I have. Now, still picturing this situation, ask yourself the following: Does having this thought (you might even call it a suicidal thought) put you in actual danger of committing suicide? Personally, I feel quite secure about myself not taking those three steps to the front and onto the railway tracks but this will be different for different individuals. In this blog, I will describe thoughts like these in more depth based on a new study we published on a construct called Thought-Action Fusion (or short: TAF) and its association with depression and suicidality.

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Childhood infections: Early fright and long-term hazard

Children get sick. A lot. Part of the reason children seemingly catch everything around us that’s bad is that their immune systems need to grow up, too. The immune system has to learn how to deal with the dangerous world around us with the difference being that it doesn’t care about cars or bullies getting in its way but instead about tiny pathogens like viruses and bacteria who can wrack havoc in our bodies. When immune systems grow up they invariably make mistakes or get taken by surprise on their way. Once this happens, not only do kids’ reddened little cheeks and large, watery eyes cause parents to do everything in their power to help, but infections in childhood can sometimes pose a real threat with children requiring hospitalisation and medical care. More often than not, this is just an early fright and no need for future bother once the acute infection is defeated. As it turns out, however, infections might pose long-term risks, too. Resulting from a collaboration between University of Cambridge and Karolinska Institutet, we just published a study in the journal JAMA Psychiatry, which shows that childhood infections might increase our risk for later development of severe mental illnesses such as schizophrenia. Strangely enough, the reason for infection posing such risk might be partly related to another risk factor for schizophrenia: low intelligence.

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Hallucinations: It’s not what you hear but expect to hear

Hallucinations are a cue word for schizophrenia and severe mental illness. Yet, in themselves, hallucinations are neither unique to schizophrenia, nor are they uniquely related to ill people. Instead, they are common in other diseases, such as Parkinson’s, and even occur in some people without any mental illnesses. Have you ever heard your name in a place where you knew nobody could have said it? Have you ever had a creepy-crawly feeling without anything bugging you? Or have you ever thought you’ve seen someone you know at first glance, yet realised later it was someone else? Chances are high that you’ve had one of these experiences because hallucinations lie on a spectrum. On one end of the spectrum, people suffering from severe diseases like schizophrenia might hear vicious voices they can’t turn off, that are terrifying and aggressive, while, on the other end, there may be such common everyday misperceptions. In fact, if you regarded my very minor examples as hallucinations, we all might be susceptible to hallucinating to an extent and a recent study published in the renowned journal Science does indeed suggest that this is the case. The study led by researchers Powers, Mathys, and Corlett has looked closely at how hallucinations come to life and suggests they may be failures in how we integrate our previous knowledge with the actual perceptual input.

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Envisioning time: Why seeing at max speed isn’t what we want

Our visual system is mesmerising. It is our predominant means of corresponding with the outside world, allowing us to navigate safely through traffic, spotting the mosquito bugging us at night, or reading blogs like this on our phone, tablet or computer. To make things visible, the very first process going on inside our bodies is the transformation of light into neuronal signals on the retinas of our eyes. To do this, our retina is equipped with so-called rods and cones, photoreceptors that turn light photons into electrical signals. Rods are good at sensing light-dark differences while cones come in three different types, each responding best to different wavelengths or colours. Fun side note: Some women have superhuman vision because they carry two recessive genes on each X chromosome resulting in the expression of a fourth type of cone, thus enabling them to perceive additional colours! Overall, each of us has about 90 million rods (mostly in the periphery of our eyes) and 5 million cones (mostly in the fovea, or the centre, of our eyes). Simplifying this, our eyes have an initial resolution of 95 million “pixels”, which is far better than the full HD resolution of 1920×1080 (~2 million) pixels on our TVs.

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What is the immune system’s role in mental health and depression?

Throughout the past century, researchers have attributed many odd, potential causes to mental health problems such as vaccines or cold, unloving mothers causing autism. Today, such explanations seem (or should seem) ridiculous but there are other scientific areas that started off being seemingly ridiculous, yet turned out to be highly relevant. One of the most recent scientific endeavours concentrates on the role of the immune system in mental health and brain functioning and, using the example of depression, I’m going to outline why this is something that is highly exciting indeed.

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